Research Progress of Wool Keratin Gene Family and Its Promoter Regulation Role
HU Xinyu1, YAO Yian1, HU Qingqing1, YU Kexin1, SHI Guoqing2, WAN Pengcheng2, DAI Rong2, GUAN Feng1*
Wool fiber is one of the most important animal products and income sources in sheep farming. With the development of protein isolation and identification technology, great progress has been made in the study of wool proteomics in recent years. The research on the composition and structure of wool has laid a foundation for the study of wool keratin encoding genes and their expression regulation procedures. This paper introduces the basic structure of wool and the regulation mechanism of wool related keratin proteins during the growth and development of wool. Keratin gene expression is highly tissue specific and spatiotemporal, and this specific expression rule is strictly regulated. The promoter is the key element of gene expression regulation. This paper further reviewed the researches on the promoters of wool keratin related genes and analyzed the regulation of the final wool traits through related transcription factors binding to the promoter specific sites. In this article, the current research progress of wool growth and development and the specific expression of wool keratin proteins were reviewed, including the aspects of wool structure, related gene expression characteristics, and specific promoters regulatory mechanisms, so as to provide theoretical reference for wool development and molecular breeding research.
CN
EN