The Effectiveness and Research Progress of Platelet-Rich Concentrate Products in Tympanic Membrane Perforation

HUANG Juntao^1,2, YUAN Zhechen^1,2, HU Shiyu^1,2, LÜ Cuiting^1,2, HU Yi^1,2, SHEN Yi^1,2*

(¹Department of Otolaryngology Head and Neck Surgery, Affiliated Lihuili Hospital of Ningbo University (Ningbo Medical Center of Lihuili Hospital), Ningbo 315040, China; ²School of Medicine, Ningbo University, Ningbo 315211, China)

Abstract:

TMP (tympanic membrane perforation) represents a common problem in otorhinolaryngology. Acute TMP can heal spontaneously but the chronic TMP require surgical interventions. Due to the limitation of conventional surgery including the requirements of general anesthesia, high costs and complicated surgical technologies, it is important to explore alternatives to solve these limitations. Platelet-rich concentrate products, including PRP (platelet-rich plasma) and PRF (platelet-rich fibrin). It is full of growth factors and white blood cell, which can effectively promote tissue regeneration and reduce the incidence of infection. As new materials in ontology, PRP and PRF have been applied in TM repair during the decades. This study will review and summarize the effectiveness of platelet concentrate products in the treatment of TM perforation according to previous studies.

CSTR: 32200.14.cjcb.2021.08.0019