Research Progress of Three-Dimensional Culture Technology in Clinical Transformation of Mesenchymal Stem Cells

FENG Chun, LI Junliang, LI Pengfei, PEI Juan, CAI Hongzhi*

(Institute of Primate Translational Medicine, Yunnan Key Laboratory of Primate Biomedical Research, Kunming University of Science and Technology, Kunming 650500, China)

Abstract:

MSCs (mesenchymal stem cells) are derived from the early development of mesoderm, and have the potential of multi-directional differentiation. They have been widely used in scientific research and preclinical trials, and show safety and effectiveness in the treatment of a variety of diseases. MSCs have broad application prospects. Because the traditional monolayer cell culture method cannot maintain the biological characteristics of MSCs for a long time, the 3D (three-dimensional) culture technology based on cell spheres, hollow fibers, biological scaffolds and microcarriers has been gradually applied to the scientific research and preclinical trials of MSCs. This paper explores the future of 3D MSCs in scientific research and clinical application by expounding the advantages of 3D MSCs and the progress of 3D MSCs in disease treatment.

CSTR: 32200.14.cjcb.2021.08.0018