Home > Browse Issues > Vol.43 No.8
Research Progress of m6A-RNA Methylation in Diffuse Large B Cell Lymphoma
ZHOU Xingli1, LI Mengxing2, WANG Jishi2*
(1School of Clinical Medicine, Guizhou Medical University, Guiyang 550004, China; 2Department of Hematology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China)
Abstract:
Although DLBCL (diffuse large B-cell lymphoma) is the most frequent subtype of non-hodgkin lymphoma, its complex pathogenesis is still far from clarity. Because of its heterogeneity, the poor prognosis of DLBCL challenges standard therapy regimen nowadays. Recently, epigenetic modification becomes a hot spot in DLBCL. Lots of researches demonstrated that m6A-RNA methylation could dynamically modulate the incidence and development of DLBCL. This paper reviews the research progress of m6A-RNA methylation in DLBCL, and provides a new strategy for the early diagnosis, treatment and prognosis of DLBCL.
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