Metabolic Regulation of Bone-Derived Hormone-Like Protein FGF23 on Extraosseous Organs

DU Yuxiang^1,2, YANG Jie², ZHANG Lingli^1*

(¹South China Normal University, Guangdong 510006, China; ²Shanghai University of Sport, Shanghai 200438, China)

Abstract:

FGF23 (fibroblast growth factor 23) is secreted by osteoblasts and osteocytes in bone and plays a key role as hormone-like proteins in complex endocrine networks. FGF23 is not only a local bone-derived factor regulating extracellular matrix mineralization, but also a systemic hormone involved in mineral metabolism. The function of FGF23 includes the regulation of phosphate reabsorption in kidney, production and catabolism of 1,25-dihydroxyvitamin D, expression of anti-aging hormone α-Klotho and balancing the dynamic of phosphate and vitamin D. This paper specifically describes the metabolic regulation of bone-derived hormone-like FGF23 on extraosseous organs, including kidney, heart, muscle and so on. This study provides new insights into the pathogenesis of hereditary hypophosphatemia, hyperphosphatemia and acquired phosphate metabolic diseases (chronic kidney disease). The in-depth study of FGF23 will provide a key target for screening gene-assisted therapy in the future.

CSTR: 32200.14.cjcb.2021.08.0015