Research Progress in the Regulation of Autophagy on Bone Diseases
LI Lu1, ZHANG Jihong1, OU Xia1, YANG Fan1, WANG Xiaofeng2*
Bone disease refers to a kind of disease caused by congenital or acquired factors that destroy normal bone metabolism and then lead to bone metabolism disorder. Bone is mainly composed of osteoclasts responsible for bone resorption, osteoblasts responsible for bone remodeling and osteocytes. The amount of bone formation in a normal adult is basically equal to the amount of bone resorption, and the two are in a dynamic equilibrium state, ensuring the integrity of bone structure and function. As an important intracellular scavenging mechanism, autophagy can realize cell metabolism and organelle renewal by forming autophagy lysosomes to degrade the damaged organelles or proteins it encapsulates. Deletion of autophagy-related genes inhibits bone resorption by osteoclasts and bone remodeling by osteoblasts. Drugs, tumor necrosis factor and other factors can cause these genes to be overexpressed. Due to the abnormal increase of bone resorption, the dynamic balance between bone resorption and bone formation is unbalanced, which eventually leads to the disorder of bone metabolism and bone disease. This article reviews the research progress among autophagy with osteoclasts, osteoblasts and bone diseases, hoping to provide ideas for targeted treatment of bone diseases.
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