Research Progress on Molecular Mechanism of ISL1 Regulating Cell Biological Behavior
NI Xiaomei, MA Li, SHI Qing*
ISL1 (insulin gene enhancer binding protein-1), a transcription factor containing two LIM domains and one HD (homeodomain), has been proven to regulate a variety of signaling pathways and biological processes. In normal tissue cells, ISL1 can precisely regulate the expression of target genes by combining with multiple transcription factors to promote cell differentiation, proliferation and other biological processes. In tumor cells, ISL1 plays an important role in the occurrence and development of cancer by affecting cell proliferation and metastasis as well as other cellular processes. This article reviews how the regulatory network involved in ISL1 affects cell proliferation and tumorigenesis; cell differentiation; cell migration, invasion and metastasis; apoptosis. In different cells, the expression of ISL1 is regulated by different signal proteins and cooperates with different molecules, which has a corresponding impact on the cell biological process. By exploring the proteins and signal pathways related to the function of ISL1, it is possible to reveal the rules of tissue development and the occurrence and development of diseases, and to provide a theoretical basis for further mechanism research, as well as a theoretical basis for the development of new drugs and clinical diagnosis.
CN
EN