Cardiac Organoid
ZHAO Dandan1, LEI Wei1, HU Shijun1,2*
Organoid is an in vitro formed three-dimensional structure, which contains different cell types and can simulate some of the structures and functions of its representative organ. The prevalence and mortality of cardiovascular disease have been on the rise, and the related research experiments are mainly based on cell and animal models. Cardiac organoid is an effective supplement to the traditional cardiovascular disease model. To a certain extent, cardiac organoid reflects the key biological characteristics of human heart more truly and accurately. Therefore, cardiac organoid has broad application prospects and unique advantages in the fields of disease mechanism research, drug evaluation, precision medicine and regenerative medicine. Here, the applications of cardiac organoid are mainly introduced as new generation of disease model in myocardial infarction, heart failure, genetic heart diseases and arrhythmia. In addition, the prospects and limitations of cardiac organoids are proposed.
CN
EN