Double-Edged Sword: the Relationship between Autophagy and Tumorigenesis and the Development of Small-Molecule Drugs
HUANG Chenkai, ZHU Xuan*
Autophagy is an important and complex physiological activity in mammalian cells, which also
affects the occurrence and progression of tumors. With the widely use of anti-tumor drugs, the problem of tumor resistance becomes increasingly prominent, which affects the prognosis of patients. At present, various kinds of small molecule drugs related to autophagy have been used to find out “one shot fits all” strategies to conquer drug resistance problem in tumor. This article reviews the molecular mechanism of autophagy in tumorigenesis and the research progress of related small molecule drugs, to have a deeper understanding of cancer-related autophagy activities and provide references for future drug development.
CN
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