Mitochondrial Proteome and Its Protein Quality Control
ZHUANG Tianpeng#, WEI Manli#, JIA Zhenwei*
Mitochondria are one of the important intracellular organelles in mammals, which not only provide energy for cells by generating ATP via oxidative phosphorylation, but also participate in the regulation of calcium homeostasis, ROS (reactive oxygen species) production, cell stress response and cell death. Mitochondria dysfunction not only leads to a variety of human diseases, but also reduces the quality of animal oocytes and early embryonic development competence. Numerous studies show that the function of mitochondria depends on the integrity and homeostasis of mitochondrial proteome. Based on this, this paper reviewed the mitochondrial proteome, mitochondrial protein transport and the formation of functional protein network, and highlighted the role of proteases, molecular chaperones, mitochondrial-derived vesicles, mitophagy and mitochondrial unfolded protein response in helping correct protein folding, removing misfolded or aggregated proteins and eliminating dysfunctional mitochondria. This might provide reference for maintaining mitochondrial health and reducing the occurance of disease incidence via the modulation of mitochondrial protein quality.
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