Mechanism and Research Progress of Hedgehog Signal Pathway
WANG Lulin, ZHANG Shuojie, TANG Wenru*, DAN Juhua*
HH (Hedgehog) signaling pathway is involved in a variety of biological processes, including cell
differentiation, cell proliferation, cell senescence, tumorigenesis, tumor malignant transformation and tumor drug resistance. Therefore, abnormal expression or mutations of genes related to the HH signaling pathway can cause a variety of diseases at different stages of biological occurrence and development. Deep insights into the role of the HH signaling pathway in various genetic diseases and tumorigenesis, as well as the development of chemotherapy resistance, are conducive to the further discovery and study of disease treatment targets. In this paper, the HH signaling pathway and its action mechanism in the occurrence and development of cancer, development, and aging are summarized. This review can provide a theoretical basis for the treatment based on the HH signaling pathway.
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