Research Progresses on Tumor Microenvironment and Metabolic Characteristics of Laryngeal Carcinoma

WANG Haoyue¹^,2,3, CHEN Jian¹^,2,3, LUO Yanbo³, CHEN Huan³, HOU Hongwei³, JI Min¹*, HU Qingyuan³*

(¹Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;²University of Science and Technology of China, Hefei 230026, China;³China National Tobacco Quality Supervision & Test Center, Zhengzhou 450001, China)

Abstract:

Laryngeal carcinoma is a common kind of head and neck cancer of which pathogenesis is not explicit, and it is one of the few cancers where the five-year survival rate has declined. More and more researches have shown that the changes of cells and stromal components, metabolic reprogramming and immune escape in the tumor microenvironment contribute to the development of cancer. Studying the laryngeal carcinoma microenvironment can add new understanding for the pathogenesis and early diagnosis of laryngeal carcinoma, and develop better treatment and prognosis strategies. Therefore, combined with the epidemiological status of laryngeal carcinoma, this review briefly summarized the composition of tumor microenvironment and its role in the development of laryngeal carcinoma and the specific characteristics of tumor metabolic reprogramming in tumor microenvironment.

CSTR: 32200.14.cjcb.2021.02.0019