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Biological Functions of KDMs in Reprogramming and Pluripotent Regulation
GAO Hui1,2,3, WEN Lan1,2,3, HU Rong1,2,3, ZHANG Changjun1,3,4, DIAO Honglu1,2,3,4*
(1Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; 2Biomedical Research Institute, Hubei University of Medicine, Shiyan 442000, China; 3Hubei Clinical Research Center for Reproductive Medicine, Shiyan 442000, China; 4Biomedical Engineering College, Hubei University of Medicine, Shiyan 442000, China)
Abstract:
Epigenetic modification is critical for the fate of stem cells and somatic reprogramming. KDMs (lysine demethylases), as key regulators of histone modification, are hot topics in regenerative medicine. Current studies have found that KDMs play important biological roles in the maintenance of stem cell pluripotency and the activation of lineage differentiation as well as the reprogramming of somatic cell nuclear transfer embryos. This article will review the latest research progress of KDMs in the field of stem cells.
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