Research Progresses of RNA Methylation Modification in Cells
ZHOU Fan, PANG Zhichang, WANG Xiaoyun*
RNA methylation is an important form of post-transcriptional modification, which is widely distributed in various types of RNA and is involved in a series of processes such as alternative splicing, localization, stability, maintenance of normal RNA structure, protein translation and RNA-protein interaction. The various types of dynamic RNA modifications reveal novel mechanism of epigenetic regulation and provide new view for exploring the regulation of gene expression and physiological activities by RNA methylated modification. This paper reviews the main progresses of RNA methylation study, and focuses on the roles and biological functions of methyltransferases (Writers), demethyltransferases (Erasers) and binding proteins (Readers) in RNA methylation.
CN
EN