Relationship between Nucleic Acid Sensing Pattern Recognition Receptors and Tumor
QIU Siyuan, YE Mao*
The innate immune system is one of the first and most important lines of defense against pathogen. It depends on a kind of receptors called PRRs (pattern recognition receptors), which recognizes pathogen-associated molecular patterns or damage-associated molecular patterns. Nucleic acid sensing pattern-recognition receptors are one of the major subsets of PRRs, which can induce the production of pro-inflammatory cytokine to trigger immunity activation by perceiving extracellular or intracellular nucleic acid, thereby protecting the host from being infected by the pathogen. Recent researches show that nucleic acid sensing pattern recognition receptors participate in progress and occurrence of tumor. This review focuses on the current knowledge about the relationship between nucleic acid sensing pattern recognition receptors and tumor.
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