Application of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Modeling of Arrhythmia
ZHENG Zequn1, LIAN Jiangfang2*
Arrhythmia involves a variety of cardiac ion channels. The desirable research model should be able to characterize various channels that form a whole action potential, and then better reveal the complex mechanism under arrhythmia. Compared with mature human cardiac electrical activity, there are inevitably great differences in heterologous expression systems or animal models. The research models established by hiPSC-CMs (human-induced pluripotent stem cell-derived cardiomyocytes) derived from individuals have almost completely replicated the characteristics of cardiac electrophysiological activities in vitro, which build up a broad platform for the study of diseases. This article provides an overview of the arrhythmia models established with hiPSC-CMs, hoping to offer some references for related work.
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