Research Progress on Abnormal Expression of miRNAs in Oncogenesis and Development of Ovarian Cancer

WANG Yu¹, YANG Xingye¹, WAN Fusheng²*

(¹The Second Clinical Medical College of Nanchang University Nanchang 330006, China; ²Department of Biochemistry and Molecular Biology, Medical College of Nanchang University, Nanchang 330006, China)

Abstract:

miRNAs (microRNAs) are a group of endogenous non-coding RNAs of approximately 22 nucleotides in length, which are involved in cell proliferation, differentiation, apoptosis and other important pathophysiological processes. It has been known that miRNAs regulate gene expression by mediating post-transcriptional silencing. miRNAs are also implicated in tumor initiation, progression and metastasis. Widely differentially expressed miRNAs are expected to prevent and treat ovarian cancer by interfering with its biosynthesis, in other words, inhibiting the expression of oncogenic miRNAs or promoting the function of tumor suppressor miRNAs can accomplish the goal. This paper reviews recent researches on roles of miRNAs in the occurrence and development of ovarian cancer, to provide new prescriptions for clinical treatment.

CSTR: 32200.14.cjcb.2020.07.0020