Research Progress of Canine Tumor Immunotherapy
LI Balun, HUA Jinlian*
At present, canine tumor diseases have become a common disease in the clinic. Surgical therapy, radiation therapy and chemotherapy as traditional treatments can improve the survival and prognosis of sick animals to a certain extent, however, these strategies still can not revolutionize the survival of sick animals. Therefore, the discovery of new tumor treatment methods is imminent. The birth of tumor immunotherapy provides us an opportunity for the prevention and treatment of canine tumors. Here, the advances in immunotherapy of canine tumors were reviewed in this paper, including the use of three immunological check points, such as PD-1 (programmed cell death 1), PD-L1 (programmed cell death ligand 1), and CTLA-4 (cytotoxic T lymphocyte antigen-4). Additionally, this paper summarizes the application prospect of adoptive cell therapy, also known as ACT. This review provides a theoretical basis and reference for the future research direction of canine tumor treatment.
CN
EN