Research Progress of AMPK Signaling Pathway in Alcoholic Fatty Liver
XIE Fotian, WANG Dongmei, LÜ Yi*
AFL (alcoholic fatty liver) is a chronic liver disease caused by long-term excessive ethanol consumption, which seriously endangers people’s health and increases social and economic burden. The pathogenesis of AFL is complex and diverse, involving the regulation of many signaling pathways. Among them, lipid metabolism disorders, oxidative stress, and inflammatory responses are involved in the development and progress of AFL to varying degrees. AMPK belongs to the Ser/Thr protein kinase family of eukaryotic cells, and plays a critical role in coordinating cellular glucose and lipid metabolism. Numerous investigations have shown that ethanol can inhibit hepatic AMPK activity and induce AFL, and activation of AMPK pathway can effectively attenuate AFL. This review focuses on the current research progress of AMPK-mediated lipid metabolism pathways in AFL to provide new ideas for the prevention and treatment of the disease.
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