Advances on Molecular Genetic Mechanisms of Mice Hair Follicle Development
WANG Zhengsen, CHEN Yixuan, LIN Chensheng*
HF (hair follicle) is an appendage of the skin. The HF is regarded as an excellent model for studying stem cell activity because it continuously proceeds through rounds of tissue regeneration. The mechanism of HF development is very complex. HF morphogenesis involves a temporal series of reciprocal interactions between the epithelium (epidermis) and its underlying mesenchyme (dermis). Transgenic mice have been used for studying the molecular mechanism of HF development and regeneration. This paper summarizes the over-expression or knock-out of key signal molecules from the epidermis and dermis during HF development in mice and prints the latest signal network that regulated HF development and cycling. It may provide a theoretical basis for an indepth understanding of HF development mechanism and hair diseases.
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