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Role of p53 in Cytoskeletal Reconstruction during Cell Proliferating and Migrating
YAN Jingyi, HAO Qian, LIU Ying, AN Shu, GUO Xiaoxi, Xu Tianrui*, YANG Yang*
(Faculty of Life Science and Technology, Kunming University of Science and Technology, University Based Provincial Key Laboratory of Screening and Utilization of Targeted Drugs, Kunming 650500, China)
Abstract:
p53 is the most important tumor suppressor, and usually exerts tumor-suppressing effect as a transcription factor. Except for its transcriptional activity, p53 and its mutants may also have effects on cell proliferation and migration though other pathways, including integrin signaling, cadherin, and Rho/ROCK signaling. These multiple functions of p53 play crucial roles in regulating actin cytoskeletal reconstruction to respond to extracellular microenvironment and oncogene activation.
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