Autophagy and Its Research Progress in Chronic Myeloid Leukemia
LIU Zhangling, TANG Rongrui, LI Juan, CHEN Yao*
Autophagy is a conserved self-degrading system in eukaryotic cells. It is the adaptable response of cells to maintain the balance of metabolism, stability of intracellular environment and promote cell survival under the harmful stimuli of nutrition or growth factor deficiency, hypoxia, microbial infection, endoplasmic reticulum stress, and so on. Autophagy may play an important role in the leukemogenesis, drug-resistance and recurrence of CML (chronic myeloid leukemia), and it has dual characteristics to promote survival and death of CML cells. Therefore, clarifying diverse roles of autophagy under different interferences, finding out specific autophagy pathways and combined use of autophagy inducer or inhibitor are helpful in the treatment of CML patients. This paper makes a summary on the research progress of autophagy in CML.
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