The Role of AMPK in Mitochondria Quality Control
YANG Xinyu, GAO Shuxin*, JIA Zhenwei*
Mitochondria are one of the important intracellular organelles in mammals that maintain mitochondria quality by regulating mitochondria biogenesis, fusion/fission and mitophagy processes. However, mitochondrial dysfunction will lead to the occurrence of various diseases. AMPK (AMP-activated protein kinase) is a key sensor of cellular energy status that is activated in response to energy stress, and regulates mitochondrial function, thereby affecting cell energy metabolism and health of organisms, suggesting that AMPK is an important regulator of mitochondrial quality. Hence, this review focuses on the structure and activation of AMPK, and its roles in the control of mitochondria quality in mammal cells, which may provide reference for modulating mitochondria quality by activating AMPK, thereby maintaining health of organisms and reducing disease incidence.
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