Home > Browse Issues > Vol.42 No.4
The Role of Macrophage in the Liver Fibrosis
XIAO Haiying1,2, WU Jianping1, WANG Anjiang1, ZHENG Xuelian3*
(1Department of Gastroenterology the First Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2Department of Gastroenterology Nanchang Third Hospital, Nanchang 330009, China; 3Department of Pharmacy, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China)
Abstract:
Liver fibrosis is a pathological manifestation characterized by excessive deposition of extracellular matrix. It is a common result of various chronic liver diseases, and eventually develops to be cirrhosis, liver cancer, and eventually death. Macrophages are involved in the development of liver fibrosis. Different subtypes of liver macrophages have different or even opposite effects on liver fibrosis. This article reviews the role of macrophage typing, the role of macrophages in the formation or degradation of liver fibrosis, and their current status in the treatment of liver fibrosis.
CN
EN