Progress of Long Noncoding RNA in the Metastasis Mechanism of Human Nasopharyngeal Carcinoma

HU Yan¹, SHEN Zhisen²*, HAO Wenjuan², YUAN Jie¹, XU Jie¹

(¹Ningbo University School, Ningbo 315211, China; ²Li Huili Hospital Affiliated to Ningbo University, Ningbo 315040, China)

Abstract:

Nasopharyngeal carcinoma is the more common and aggressive head and neck tumor. With the development of comprehensive therapies such as chemoradiotherapy and molecular targeting therapy, the mortality rate of nasopharyngeal carcinoma has decreased significantly. The prognosis of patients in early stage is favourable, while the prognosis of patients in middle and late stage or with recurrence and metastasis is still poor. Therefore, it is important to understand the molecular mechanism of nasopharyngeal carcinoma metastasis fully. At present, LncRNA (long noncoding RNA) is popular in tumor researches. More and more studies have found that LncRNAs play an important role in the metastasis mechanism of nasopharyngeal carcinoma, including EMT (epithelial mesenchymal transformation), degradation of ECM (extracellular matrix) and microvascular formation. This article reviews the metastasis mechanism of LncRNAs in nasopharyngeal carcinoma.

CSTR: 32200.14.cjcb.2020.03.0021