Research Progress of the Cytoprotective Properties of Melatonin on the Ovary
FAN Yihui, LAI Dongmei*
Melatonin is a neuroendocrine hormone that mainly synthesized and secreted by the pineal gland. It is known to regulate circadian rhythms of many biological and reproductive functions and exerts physiological roles in various peripheral organs including ovary. ROS (reactive oxygen species) are produced within the ovarian follicles during reproductive processes. Melatonin, is implicated in the regulation of reproductive physiology through receptor-dependent and receptor-independent mechanisms. Recent studies focus on the essential role of melatonin in the regulation of autophagy. This review summarizes new findings related to beneficial effects of melatonin on the ovarian function and the mechanisms of melatonin on the ovarian follicles.
CN
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