RNA and Protein in Exosomes of Mesenchymal Stem Cell

LUO Chao^1,2, HUANG Lei^1,2, WU Pingping³, FEI Jiuwang^1,2, GU Yurong²*

(¹Nanchang University Graduate School of Medicine, Nanchang 330006, China; ²Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; ³Affiliated Hospital of Jiujiang University, Jiujiang 332000, China)

Abstract:

Mesenchymal stem cell exosomes are 50-200 nm extracellular vesicles that are secreted into the extracellular environment when the multivesicular bodies in MSC fuse with the plasma membrane. MSC exosomes contain typical exosome-associated proteins such as TSG101, CD9, CD81 and carry a variety of RNAs. It has been gradually recognized that exosomes act by delivering their protein and RNA contents to recipient cells. Therefore, the therapeutic potential of MSC exosomes may be due to their specific protein or RNA content. In this paper, the mechanism of action of exosome protein and RNA was explored, and it was proposed that MSC exosome might exert its effect through protein rather than RNA.

CSTR: 32200.14.cjcb.2020.03.0019