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Research Progress of New Autophagy-Related Protein Atg101
MA Jingyuan, YANG Ying, HAN Junfeng*
(Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People’s Hospital, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai 200233, China)
Abstract:
Autophagy (macroautophagy) is a unique life phenomenon of eukaryotic cells. Autophagy not only controls the degradation of proteins and organelles in cells, but also plays pivotal roles in growth and maintain cellular homeostasis. From yeast genetic studies, more than 40 ATG genes have been identified up to now. Atg101 is a new autophagy-related protein which has been recently discovered. Currently, the molecular structure and function of Atg101 have been gradually elucidated, and its role in disease development has also been studied. This review summarizes recent research advances in the structure and function of Atg101.
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