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Application of RNA Interference in the Study of Mammalian Oocyte and Early Embryo Development
Hui-Li Tong, Shu-Feng Li, Yun-Qin Yan*
Histology and Embryology Unit, College of Biological Sciences, Northeast Agriculture University, Harbin 150030, China
Abstract: RNAi is a phenomenon of post-transcriptional gene silencing， initiated by special double-stranded RNA (dsRNA) in eukaryotic cells. In recent years， the mechanism of RNAi has been clearly illustrated， and it has been widely used in the study of gene function. In this paper， we have summarized the mechanism of reaction， application， problem and prospect of RNAi in mammalian oocytes and early embryos.
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