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Long Non-Coding RNA UCA1 and Tumor Drug Resistance
ZHENG Bin1,2, WANG Yu1,2*
(1The Second Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang 712046, China; 2Medical Research and Experiment Center, Shaanxi University of Chinese Medicine, Xianyang 712046, China)
Abstract:
As an efficient treatment for malignant tumor, chemotherapy has been used widely in treating various tumors. Although the use of chemotherapy drugs has significantly improved patients’ survival rate and prognosis, the rapid development of multidrug resistance will lead to therapeutic failure. In the past few years, lncRNA UCA1, as a multi-drug resistance gene, has been found to mediate drug resistance in a great number of tumors. This manuscript reviews the progress of UCA1 in drug resistance and prospects the development and challenge in the future.
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