Functions of Histone Demethylase UTX in Developments and Diseases
GAO Meng, JIANG Qi, HUANG Xingwei, WANG Nan, PANG Nan, LEI Lei*
UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome) is a histone demethylase that targets tri-methyl groups on H3K27 (lysine 27 of histone H3). UTX dynamically regulates the methylation of H3K27 together with specific methyltransferase PRC2. Furthermore, UTX is a member of MLL3/MLL4 H3K4 methyltransferase complex. UTX is indispensable for biological development, as it is needed for embryonic development, HOX gene expression and somatic cell reprogramming. Constitutional mutation of UTX has a strong relationship with Kabuki Syndrome, a special hereditary disorder. Meanwhile, UTX is identified as a tumor suppressor which regulates multiple human cancers. Here, we summarize the functions of UTX in developments and diseases with the current research progresses, and explore the effect of UTX in somatic cell reprogramming combined with our study.
CN
EN