Research Progress of RNA-Binding Proteins in Fate Determination of Pluripotent Stem Cells
WANG Xiuqin#, YIN Mengran#, XIA Qing, WANG Lisha, QIN Baoming, YAO Hongjie*
RNA binding proteins are a class of proteins that interact with RNA through their RNA binding domains, and play very important roles in a variety of regulatory pathways, from RNA metabolism (including alternative splicing, stabilization of RNA, translation) to epigenetic modification. It has been reported that transcriptional factors, epigenetic modifications and extracellular signaling pathways play the important roles in regulating pluripotency maintenance and differentiation of pluripotent stem cells and somatic cell reprogramming. However, there are few reports on the role of RNA binding proteins in stem cell fate determination. In this review, we summarize the roles of RBPs in regulating pluripotency maintenance of pluripotent stem cells and somatic cell reprogramming through regulating alternative splicing, mRNA stability, translation level, microRNA metabolism and histone modifications.
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