NAD+ and Cellular Senescence
WANG Jie, LIU Lin, SONG Guanbin*
NAD+ (nicotinamide adenine dinucleotide) is an essential cofactor of key enzymes in glycolysis, TCA (tricarboxylic acid) cycle and oxidative phosphorylation, which participates in many physiological and pathological activities, such as cellular metabolism, energy synthesis, and repair of injured DNA. In recent years, studies have found that NAD+ shows a downward trend during the body or cell senescence,whlie replenishment of NAD+ or its precursors significantly delayed cell senescence and improved lifespan. Therefore, the application of NAD+ and its precursors has attracted widespread attention. In this review, we will briefly summarize the current research progresses about the relationship between the NAD+ and its precursors and cellular metabolism, senescence and the involved mechanisms. A better understanding of their relationship will provide an important reference for basic and applied studies on cellular senescence.
CN
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