Lineage Specification of Three Germ Layers of Early Mouse Embryo by Spatiotemporal Transcriptome
CUI Guizhong1, PENG Guangdun2,3, JING Naihe1*
Cell fate specification in the development of zygote into embryo proper is regulated at multiple levels. During the early embryonic development of mammals, formation of the three primary germ layers, ectoderm, mesoderm, and endoderm, as the results of gastrulation, provides a blueprint for morphogenesis and organogenesis. However, a comprehensive genome-wide molecular annotation of the mechanisms that determine the tissue architecture and lineage specification of the three germ layers has not been clarified. We show that the entire process of the specification of the ectoderm, mesoderm and endoderm lineages is revealed by analyzing the spatiotemporal transcriptomes of mouse early embryos.
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