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Relationship Between Angiopoietin-Like Protein 3,Lipid Metabolism and Atherosclerosis
Wang Jingqiao1,2, Wang Shuangshuang2, Wang Jianan1,3, Chen Xiaomin1,2*
(1Zhejiang University School of Medicine, Hangzhou 310000, China; 2Department of Cardiology, Ningbo Hospital of Zhejiang University, Ningbo 315000, China; 3Department of Cardiology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China)
Abstract:
Dyslipidemia is a major risk factor for atherosclerosis and atherosclerotic cardiovascular disease, lipid-lowering therapy is always the foundation of atherosclerotic cardiovascular disease treatment. Angiopoietinlike protein 3 is considered to be an effective and promising lipid-lowering therapeutic target. Targeted inhibition of ANGPTL3 has the effect of lowering plasma lipid levels and inhibiting atherosclerosis. This article reviews the relationship between ANGPTL3 and lipid metabolism and atherosclerosis.
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