Effects of Compression on Chondrocytes

Osteoarthritis (OA) is a chronic degenerative disease characterized by articular cartilage degeneration, subchondral bone remodeling, osteophyte formation, intra-articular synovial inflammation, and extensive angiogenesis. Its occurrence is affected by many factors such as genetics, environment, metabolism, biochemistry and mechanical stress, among which mechanical stress anomalies are the main cause. In the process of OA caused by abnormal mechanical stress, chondrocytes will change. Compressive stress is a kind of mechanical stress. Recent studies have shown that compressive stress can affect the morphology, metabolic state, phenotype and cell viability of chondrocytes, which in turn affects the development of OA. Therefore, this paper reviews the literature on chondrocytes under compression in recent years to provide theoretical basis for the study of OA mechanism and treatment.

CSTR: 32200.14.cjcb.2019.05.0023