The Research Development of miR-21 in Liver Diseases

Ge Rui¹, Zhao Gangjun^1,2, Li Huan^1,2, Li Hong²*, Zhang Xie²

(¹Ningbo University School of Medicine, Ningbo 315211, China; ²Ningbo Medical Centre of Lihuili Hospital, Ningbo 315040, China)

Abstract:

MicroRNAs are about 22 nucleotide that regulate gene expression at the post-transcriptional level by binding messenger RNA transcripts. Dysregulation of miRNAs affects a wide range of cellular processes including cell proliferation and differentiation. It is up-regulated in almost all types of cancers, promotes cancer cell proliferation, migration, and survival and therefore was classified as an onco-miR.It plays an important role in the occurrence of hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. This article summarizes the latest developments in miR-21 in liver diseases in order to better apply to clinical diagnosis and treatment.

CSTR: 32200.14.cjcb.2019.05.0022