P2X7 Receptor and Inflammation-Related Diseases
Zhang Yunfang, Li Mingxuan, Peng Xiaoxiang, Zhao Ronglan*
The P2X7 is a ATP-gated cationic channel receptor and widely expressed in a variety of immune cells, where its activation triggers and aggravates the inflammatory reaction. When cells are damaged, hypoxic or inflammatory, large-scale ATP is released into the extracellular matrix, then activates P2X7 receptor. Activated P2X7 receptor induces the release of inflammatory cytokines (IL-1β, IL-18, etc.) by mediating the activation of NLRP3 inflammasome and regulating gene transcription, etc, thus participating in various inflammatory diseases, such as diabetic nephropathy, systemic lupus erythematosus and so on. In recent years, extracellular ATP-P2X7 receptor signaling pathway has become one of the most popular pathways in inflammatory diseases. Many studies have shown that the P2X7 receptor is a potential target to treat inflammatory diseases. In this review, we discuss the relationship between P2X7 receptor and inflammatory related diseases.
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