Research Progress on Somatic Cell Reprogramming Mechanism
Zhou Jianfeng, Guo Mingyue, Wang Yixuan*, Gao Shaorong*
Somatic cell reprogramming is one of the research focuses in life sciences and regenerative medicine fields. At present, several methods such as somatic cell nuclear transfer, cell fusion and transcription factor induction can achieve in vitro reprogramming. A large number of epigenetic modifications play a key role in the reprogramming process. Therefore, understanding the dynamic changes of epigenetic modifications and their respective roles helps to better comprehend and apply reprogramming techniques. This article briefly reviews the development history and research progress of somatic cell nuclear transfer technology and induced pluripotent stem cell technology, and discusses the epigenetic mechanisms existing in these two reprogramming processes.
CN
EN