Overview of RNA m6A Methylation Modification

Zhang Liyuan¹, Yang Yungui^1,2,3*

(¹Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; ²Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; ³University of Chinese Academy of Sciences, Beijing 100049, China)

Abstract:

RNA contains multiple modifications, such as N6-methyladenosine (m6A), 1-methyladenine (m1A), 5-methylcytosine (m5C), pseudouridylation (Ψ), etc., among which m6A is the most abundant one that has been most thoroughly studied so far. As the development of m6A detecting techniques and the emerging of other novel technologies, such as single base resolution sequencing, a variety of m6A modification-related regulatory enzymes have been identified, facilitating the interpretation of their potential biological functions. Here, we mainly focus on the m6A regulatory proteins, its distribution features and detecting techniques, as well as its biological functions and correlation with different histological cancers. Future challenges and perspectives of RNA m6A modification are also discussed.

CSTR: 32200.14.cjcb.2019.05.0002