Mediator in Transcriptional and Epigenetic Regulation
Li Chonghui1, Cao Dan1, Wang Gang2*
The transcription of genes is controlled strictly and precisely in eukaryotes. The Mediator complex orchestrates multiple transcription factors with transcriptional machinery to regulate the initiation, elongation and termination of transcription. In addition, epigenetic regulations including histone modifications, higher order chromatin structure are also crucial for the transcriptional regulation. And dysfunctions of transcriptional regulation often lead to developmental abnormalities and diseases. This paper mainly focuses on the molecular mechanisms and functional roles of the Mediator Complex in transcriptional and epigenetic regulation, including dynamic changes in chromatin structure.
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