Comparative Analysis of the Role of Autophagy Intervention in Permanent and Transient Cerebral Ischemia
Guo Tao, He Hongyun, Dong Lingling, Ren Lu, Deng Yihao*
In recent years, ischemic stroke has been a hot topic for researchers. According to the clinical situation of patients with middle cerebral artery ischemia who do not get recanalization and achieve recanalization, it is divided into permanent cerebral ischemia and transient cerebral ischemia. A large number of literatures have reported the role of autophagy in two kinds of ischemic animals or cell models. However, due to the influence of complex pathological factors of autophagy and cerebral ischemia, the conclusions are different, and there is no unified summary. So this paper, through comparing the similarities and differences between the two, appropriately adjusting the influence factors as well as analyzing the causes, we want to use the detection and regulation methods of autophagy level to intervene, so that the dual role of autophagy in ischemic stroke will eventually change from injury to a single neuroprotective function effect. All the studies are aimed at providing a valuable reference for the treatment of permanent and transient cerebral ischemia in autophagy interventions in basic and clinical studies. Therefore, this article makes a review.
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