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The Biological Properties of Spermatogonial Stem Cells
Xue-Ming Zhang1, De-Xue Li1,3*, Jia-Ao Yu2, Zhan-Peng Yue1
1College of Animal Husbandry and Veterinary Medicine, Jilin University, Changchun 130062, China; 2 The Frist Hospital,Jilin University, Changchun 130021, China; 3Academy of Military Medical Sciences, Beijing 100085, China
Abstract: Spermatogonial stem cells (SSCs)， the postnatal male germline stem cells， reside on the base membrane of the seminiferous tubules in testes. They are not only capable of self-renewing and differentiating but also the only adult stem cells in normal postnatal body that undergo self-renewal throughout life and transmit gene to offspring. Remarkable progresses involving the isolation， characterization， culture， cryopreservation， transgenic manipulation， and transplantation of these unique cells have been made since the report of SSCs transplantation technique. With the aid of this functional assay， the biological properties of SSCs were researched deeply in recent years. Based on the related reports most recently and our previous work， we aim to provide a comprehensive overview of the biological properties of SSCs.
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