Home > Browse Issues > Vol.41 No.3
Regulation of Spindle Plasticity and Dynamics
Liu Xing, Liu Xu, Yao Xuebiao*
Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, University of Science and Technology of China, Hefei 230026, China
Abstract: Accurate chromosome segregation depends on the spatiotemporal orchestration of centromere assembly， spindle and astral microtubule plasticity. The spindle plasticity control and regulation have been exciting subjects for intensive cross-disciplinary research over the last three decades. Biochemical characterization has identified a diversified spectrum of post-translational modifications while structure studies have determined the atomic determinants functional activity. However， it has remained elusive as to the relationship between dynamics of biomolecular conformation and functional activity in space and time. In addition， it is poorly illustrated as whether regulatory mechanisms underlying two dimensional control of mitotic spindle plasticity can be translated into the molecular delineation of cell cycle regulation in three dimensional cultures such as organoids. This article summarizes the progresses and perspectives of spindle plasticity and molecular dynamics.
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