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Targeting and Therapeutic Effects of Iron Oxide-Doxorubicin Nanocomplex on Mice Breast Cancer
Dai Yinhai1*, Qiu Chunli2, Wang Mao1, Ji Wenxin1, Mao Ning1
1Tumor Breast Surgery, The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, 712000, China; 2Department of General Surgery, Xianyang Central Hospital, Xianyang 712000, China
Abstract: This work was aim to evaluate the targeting and therapeutic effects of ferrous iron oxidedoxorubicin nanocomplex on breast cancer in mice. The carboxymethyl chitosan modified nano iron oxide (OCMCSPIO) prepared by precipitation method was composed of nanocomposites through the electrostatic interaction between the carboxyl group of carboxymethyl chitosan and the amino group of doxorubicin (DOX). The prepared SPIO and OMCS-SPIO were characterized by transmission electron microscopy， Fourier transform infrared spectroscopy and superconducting quantum interference magnetometer， and their morphology characteristics were observed. In vivo imaging of mice was used to observe the targeting effect of the prepared nanocomplexes on tumor-bearing mice. Tumor growth inhibition experiments in tumor-bearing mice examined the therapeutic effects of nanocomplexes on tumors. The results showed that the prepared SPIO particle size was about 10 nm， and the superparamagnetism of nano iron oxide was retained after doxorubicin. Live imaging of mice showed that nanocomplexes could be enriched in the tumor area. Mouse tumor growth inhibition experiments showed a better tumor suppressor effect than DOX alone. The results indicated that the prepared iron oxide-doxorubicin nanocomplex has tumor targeting and tumor suppressor effect.
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