Home > Browse Issues > Vol.40 No.10
Progress on Chemical Modification of Protein
Li Wenjing, Li Lijun*, Wu Zheyu, Liu Jianan, Gong Jianye, Liao Hui, Liu Xiaoqin
College of Food and Biological Engineering, Jimei University, Xiamen 361000, China
Abstract: Protein is the basic substance of life and its specific spatial structures were very important for the function. Changing the structure and function of proteins by using chemical modification is always the focus in the study of protein engineering. In some reports， many enzymes and chemical modifiers have been used to modify and convert the characteristics of proteins. The former method altered the protein post-translated and the latter conjugated small molecules to protein. Therefor， on the basis of analyzing and summarizing the existing related literatures， we present the methods about chemical modification of protein， including terminal modification， side-chain modification about thiol， disulfide bond and phosphorylation.
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