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Research Progress of lncRNA and miRNA Regulatory Relationship and ceRNA Relationship in Diseases
Shen Zhengjie, Zhu Yinyin, Shen Fanhan, Ablimt·Muhtar, Liao Qi*
Department of Preventive Medicine, Medicine School of Ningbo University, Ningbo 315221, China
Abstract: Regulatory non-coding RNA (ncRNA) is one of the hot spots to research in recent years. It mainly includes microRNA (miRNA) and long non-coding RNA (lncRNA). LncRNA is a kind of functional non-coding RNA with more than 200 nucleotides in length， while miRNA is a kind of short chains of non-coding RNA about 20 nucleotides that widely distributed in genome. They both play key regulatory roles in cell growth， proliferation and differentiation. At the same time， relevant studies have shown that there are complex regulatory relationships between lncRNA and miRNA， which play important roles in the occurrence and development of many diseases， especially cancer. This review mainly focused on the research progress of the interaction between lncRNA and miRNA and ceRNA network.
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