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The Progress in the Roles and Mechanisms of Nonsense Mediated mRNA Decay in the Development of the Nervous System and Neurological Diseases
Shen Xiya1, Xuan Lina1, Du Leilei1, Li Tangliang2, Huang Zhihui1*, Xu Xingxing1*
1Institute of Neuroscience, Basic Medical College, Wenzhou Medical University, Wenzhou 325035, China; 2Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China
Abstract: Nonsense-mediated mRNA decay (NMD) is a common， highly conserved mRNA quality monitoring system in eukaryotic cells， which prevents production and accumulation of abnormal proteins by recognizing and degrading mRNAs containing premature termination codons， long 3′ untranslated regions and upstream open reading frame. Recent studies show that NMD can regulate the stability of normal gene transcription， plays an important role in neurogenesis， synaptic plasticity， and dysfunction of NMD involves in neurological diseases of the nervous system. This article reviews the roles and mechanisms of NMD in the development of the nervous system and neurological diseases， in order to provide a theoretical basis for the treatment of neurological diseases.
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