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The Role of Extracellular Vesicles in the Pathogenesis， Diagnosis and Treatment of NAFLD
Yang Guang, Dou Lin, Shen Tao, Tang Weiqing, Man Yong, Li Jian, Huang Xiuqing*
The MOH Key Laboratories of Geriatrics, Beijing Hospital, National Center of Geriatrics, Beijing 100730, China
Abstract: Nonalcoholic fatty liver disease (NAFLD) is not only one of the most important public health problems in the 21th century， but also the main cause of chronic liver disease in our country. Intercellular communications play a great role in the progress of NAFLD. Recently， extracellular vesicles (EVs) become a novel mediator for intercellular communications which is highly concerned. EVs act as cell-to-cell messengers by carrying lipids， proteins， DNAs， mRNAs and non-coding RNAs， which are involved in several physiological and pathological processes. So far， the studies of EVs on the pathogenesis， treatment and diagnosis of NAFLD are very limited. However， we conclude that EVs play an important role in the NAFLD disease development from the previous studies. Here， we summarize the role of EVs in the pathogenesis of NAFLD and discuss the potential clinical applicatons of EVs as predictive biomarkers and therapies.
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