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Gene Structure， Evolution and Function of RIG-I
Li Na, Gao Lili, Zheng Kang, Liu Xi, Chen Meishan, Li Ao*, Pang Qiuxiang*
School of Life Sciences, Shandong University of Technology, Zibo 255049, China
Abstract: RIG-I (retinoic acid-inducible gene-I) is a receptor that recognizes viral RNA in the cytoplasm and is widely distributed in many tissues and cells. Its structure includes an N-terminal caspase recruitment domain (CARD)， RNA helicase domain， and C-terminal regulatory or repressed domain (CTD/RD). Recent studies have found that in addition to its antiviral function， RIG-I is also involved in antibacterial， anticancer， and regulates biological processes such as cell proliferation， differentiation and apoptosis. Therefore， in order to understand RIG-I more systematically， the gene structure， evolution and function of RIG-I were reviewed in this paper in order to provide reference for the study of pathogen infection and cancer.
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